{"id":1741,"date":"2022-06-03T14:54:18","date_gmt":"2022-06-03T12:54:18","guid":{"rendered":"https:\/\/cosmetosciences.fr\/selective-suppression-of-cells-for-the-safety-of-cosmetic-ingredients\/"},"modified":"2022-12-07T09:41:15","modified_gmt":"2022-12-07T08:41:15","slug":"selective-suppression-of-cells-for-the-safety-of-cosmetic-ingredients","status":"publish","type":"post","link":"https:\/\/cosmetosciences.fr\/en\/selective-suppression-of-cells-for-the-safety-of-cosmetic-ingredients\/","title":{"rendered":"Selective suppression of cells for the safety of cosmetic ingredients"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(255,255,255,0)” top_divider_style=”curve” top_divider_color=”#8FB459″ top_divider_height=”9px” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” header_font=”Comfortaa||||||||” header_font_size=”34px” header_2_font=”Comfortaa|700|||||||” header_2_text_align=”center” header_2_line_height=”1.2em” global_colors_info=”{}”]

EXCEL\nSelective suppression of cells for the safety of cosmetic ingredients\n<\/h1>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” custom_margin=”-8px|auto||auto||” custom_padding=”4px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” text_font=”||on||||||” text_font_size=”18px” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]

The Excel project aims to develop new compounds to chemically \u2018extinguish\u2019 two target proteins: the first is responsible for the formation of sensitisers, and the second, which is present in skin, targets endocrine disruptors.\nThrough its technological innovations, it seeks to contribute to making the introduction of new cosmetic substances on the market completely safe.\n<\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” header_2_font=”Comfortaa|700|||||||” header_2_line_height=”1.2em” global_colors_info=”{}”]

The introduction of new cosmetic substances with no risk to the health of consumers\n<\/h2>[\/et_pb_text][et_pb_image src=”https:\/\/cosmetosciences.fr\/wp-content\/uploads\/2022\/06\/extinction-cellulaire-selective.jpg” alt=”Selective suppression of cells for the safety of cosmetic ingredients” title_text=”suppression-cell-selective” _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” text_font_size=”15px” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]

The cosmetics industry has recently had to face increasingly complex conditions for placing its products on the market. The only way of identifying and quantifying the impact of a substance on the consumer that is recognised today by the regulatory agencies is by evaluating the effects of that product on cellular models and defining the AOPs (adverse outcome pathways), which can be likened to \u2018cards\u2019 representing mechanisms of toxicity by identifying the molecular players involved in the various cellular signalling pathways. This is why this research project on selective cell suppression is so important.<\/p>[\/et_pb_text][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” header_2_font=”Comfortaa|700|||||||” header_2_line_height=”1.2em” global_colors_info=”{}”]

Qualifying with certainty the metabolisation of active ingredients and compounds in cosmetic formulations\n<\/h2>[\/et_pb_text][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” text_font_size=”15px” global_colors_info=”{}”]

The use of these chemically \u2018knocked out\u2019 (KO) biological systems will allow us to determine the target\u2019s involvement in a metabolic pathway and the likelihood of it activating a cellular signalling pathway that could present a risk to the consumer\u2019s health.\"QualifyingThis KO status will be obtained via the design and validation of PROTACs (proteolysis targeting chimera) for the targets in question.
These models will also allow us to characterise known ingredients and formulations by substantiating\/characterising their toxicological profile, which will make it possible to predict any interactions between the ingredients of a formula.<\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ _module_preset=”default” background_color=”#f2f2f2″ custom_padding=”20px|20px|20px|20px|false|false” border_radii=”off||20px|20px|” border_width_left=”6px” border_color_left=”#969696″ global_colors_info=”{}”]Project partners<\/span>\n\n2 ACADEMIC laboratories<\/strong>\n