{"id":1746,"date":"2022-06-24T15:47:00","date_gmt":"2022-06-24T13:47:00","guid":{"rendered":"https:\/\/cosmetosciences.fr\/project\/icoa-laboratory-umr-7311\/"},"modified":"2022-12-05T15:12:43","modified_gmt":"2022-12-05T14:12:43","slug":"icoa-laboratory-umr-7311","status":"publish","type":"project","link":"https:\/\/cosmetosciences.fr\/en\/project\/icoa-laboratory-umr-7311\/","title":{"rendered":"ICOA Laboratory- UMR 7311"},"content":{"rendered":"

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ICOA \u2022 UMR 7311
Institute of Organic and Analytical Chemistry<\/h1>\n

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The Institute of Organic and Analytical Chemistry – ICOA<\/strong> is a research laboratory under the supervision of the University of Orl\u00e9ans and the CNRS (UMR 7311), located on the campus of the university. The mission of the laboratory is the identification of new bioactive molecules that could have therapeutic and cosmetic applications.<\/p>\n

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Cosm\u00e9tosciences research topics:<\/h2>\n

Naturalness and eco-friendly processes and Biological activity and safety<\/h2>\n

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The scientific approach extends from the design of new structures by molecular modelling, to the synthesis of new organic molecules (heterocyclic compounds, sugar derivatives and nucleoside analogues), to the extraction and characterisation of natural molecules by the most effective separation and extraction techniques and by mass spectrometry, and to enzymology, to learn about the receptors of certain bioactive molecules .<\/p>\n

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The ICOA\u2019s research is conducted by 5 teams. 4 of them are involved with Cosm\u00e9tosciences<\/h3>\n

[\/et_pb_text][et_pb_toggle title=”The Structural Bioinformatics and Cheminformatics team” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#C8B3A3″ closed_toggle_background_color=”#DD98A6″ icon_color=”#FFFFFF” use_icon_font_size=”on” icon_font_size=”30px” open_icon_color=”#7D5A40″ open_use_icon_font_size=”on” open_icon_font_size=”30px” _builder_version=”4.17.6″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|700|||||||” custom_margin=”||8px|||” border_radii=”on|8px|8px|8px|8px” border_color_all=”#DD98A6″ global_colors_info=”{}”]<\/p>\n

The ICOA\u2019s Structural Bioinformatics and Cheminformatics team of the University of Orl\u00e9ans is developing and using new in silico methods applied to the understanding of molecular systems and to biomolecular interactions in the field of therapeutic innovation, cosmetics and analytical chemistry.<\/p>\n

The methods used are molecular modelling, approaches based on the structure of proteins or ligands, cheminformatics, structural bioinformatics, the development of relational databases and data viewing methods.<\/p>\n

[\/et_pb_toggle][et_pb_toggle title=”GlycoBio&Chemistry research team” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#C8B3A3″ closed_toggle_background_color=”#DD98A6″ icon_color=”#FFFFFF” use_icon_font_size=”on” icon_font_size=”30px” open_icon_color=”#7D5A40″ open_use_icon_font_size=”on” open_icon_font_size=”30px” _builder_version=”4.17.4″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|700|||||||” custom_margin=”||9px|||” border_radii=”on|8px|8px|8px|8px” border_color_all=”#DD98A6″ global_colors_info=”{}”]The GlycoBio&Chemistry research team is interested in the development of new methodologies for the synthesis of glycosylated molecules such as glycosaminoglycans, glycomimetics (iminosugars, thiosugars) as well as the monomers, oligomers and polymers of biosourced surfactants. And also in chemo-enzymatic synthesis and the study of the structure and action mechanisms of glycosyltransferase and glycosidases to perform molecular engineering.[\/et_pb_toggle][et_pb_toggle title=”The Heterocycles, Nucleosides and Imaging Agents team (HNAI)” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#C8B3A3″ closed_toggle_background_color=”#DD98A6″ icon_color=”#FFFFFF” use_icon_font_size=”on” icon_font_size=”30px” open_icon_color=”#7D5A40″ open_use_icon_font_size=”on” open_icon_font_size=”30px” _builder_version=”4.17.4″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|700|||||||” custom_margin=”-1px||9px|||” border_radii=”on|8px|8px|8px|8px” border_color_all=”#DD98A6″ global_colors_info=”{}”]The Heterocycles, Nucleosides and Imaging Agents team is developing methodologies for the synthesis and functionalisation of heterocycles and rare heteroaromatics, as well as nucleoside and nucleotide analogues.
\nIt is synthesising new chemical tools with a view to their use in medicinal biology and chemistry \u2018Chemical Biology\u2019: probes and sensitisers for in vitro and in vivo imaging for the pharmaceutical and cosmetics field and is developing innovative methods for detecting and evaluating the toxicity\/safety of bioactive molecules.[\/et_pb_toggle][et_pb_toggle title=”The Analytical Strategies, Affinities and Bioactive ingredients team (SAAB)” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#C8B3A3″ closed_toggle_background_color=”#DD98A6″ icon_color=”#FFFFFF” use_icon_font_size=”on” icon_font_size=”30px” open_icon_color=”#7D5A40″ open_use_icon_font_size=”on” open_icon_font_size=”30px” _builder_version=”4.17.4″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|700|||||||” custom_margin=”-1px||8px|||” border_radii=”on|8px|8px|8px|8px” border_color_all=”#DD98A6″ global_colors_info=”{}”]The ICOA\u2019s Extraction & Analysis of Bioactive Molecules team is developing methods for analysing molecules of interest that are present in trace amounts in complex environments. And also new eco-friendly methodologies for the extraction, separation, isolation, characterisation,\u2019identification, and dosage of the primary and secondary metabolites present in plants. The biological activities of extracts that are of cosmetic or therapeutic interest are evaluated by chemical and biochemical in vitro reactions. Chemometric and and bioinformatic tools are also developed to optimise analysis conditions, to perform mapping and for complex sample comparisons. [\/et_pb_toggle][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.6″ _module_preset=”default” header_2_font=”Comfortaa|700|||||||” header_2_line_height=”1.2em” header_3_line_height=”1.2em” global_colors_info=”{}”]<\/p>\n

Experimental facilities<\/h3>\n

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