{"id":1839,"date":"2022-07-21T12:02:53","date_gmt":"2022-07-21T10:02:53","guid":{"rendered":"https:\/\/cosmetosciences.fr\/project\/synthesis-and-isolation-of-bioactive-molecules-laboratory-simba-ea-7502\/"},"modified":"2022-12-05T15:16:08","modified_gmt":"2022-12-05T14:16:08","slug":"synthesis-and-isolation-of-bioactive-molecules-laboratory-simba-ea-7502","status":"publish","type":"project","link":"https:\/\/cosmetosciences.fr\/en\/project\/synthesis-and-isolation-of-bioactive-molecules-laboratory-simba-ea-7502\/","title":{"rendered":"Synthesis and Isolation of Bioactive Molecules laboratory SIMBA – EA 7502"},"content":{"rendered":"

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SIMBA \u2022 EA 7502
\nSynthesis and Isolation of Bioactive Molecules laboratory<\/h1>\n

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The Synthesis and Isolation of Bioactive Molecules laboratory (SIMBA)<\/strong> is an EA7502 host team from the University of Tours created in January 2018, which works on small molecules with the aim of therapeutic application. These are obtained by synthetic chemistry or isolated from plants or algae.<\/p>\n

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Cosm\u00e9tosciences research topic:<\/h2>\n

Naturalness and eco-friendly processes<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.17.6″ _module_preset=”default” text_font_size=”15px” global_colors_info=”{}”]The SIMBA team is therefore developing new methodologies for the synthesis of heterocyclic and\/or fluorinated compounds, based on organometallic chemistry, extraction and analysis by various chromatographic methods (HPTLC, CPC) of natural substances, and the use of deep eutectic solvents.
\nThe molecular diversity obtained can be applied to infectious diseases, oncology and cosmetology.[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” _builder_version=”4.17.4″ _module_preset=”default” custom_padding=”4px||18px|||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.6″ _module_preset=”default” header_2_font=”Comfortaa|700|||||||” header_2_line_height=”1.2em” header_3_line_height=”1.2em” global_colors_info=”{}”]<\/p>\n

The SIMBA\u2019s research is conducted by 2 teams.\u2028One team is involved in Cosm\u00e9tosciences<\/h3>\n

[\/et_pb_text][et_pb_toggle title=”Eco-friendly biomass extraction team” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#C8B3A3″ closed_toggle_background_color=”#DD98A6″ icon_color=”#FFFFFF” use_icon_font_size=”on” icon_font_size=”30px” open_icon_color=”#7D5A40″ open_use_icon_font_size=”on” open_icon_font_size=”30px” _builder_version=”4.17.6″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|700|||||||” custom_margin=”||8px|||” hover_enabled=”0″ border_radii=”on|8px|8px|8px|8px” border_color_all=”#DD98A6″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

The component of the laboratory working on eco-friendly biomass extraction is studying the use of Natural Deep Eutectic Solvent (NaDES) as an advantageous alternative for biomass extraction. NaDES are considered to be a new generation of ionic liquids, consisting of a hydrogen bond acceptor (HBA) and a hydrogen bond donor (HBD), the combination of which forms a hydrogen bond network resulting in the lowering of the melting point of the solids mixture.<\/p>\n

The team is currently working on the development of an innovative library of new NaDES, apolar ones in particular, from their design to their characterisation, and including the development of new processes for obtaining them.\u2028These NaDES are used for the extraction of microalgae and plants in partnership with manufacturers, with the aim of enhancing their metabolites. A multi-step biorefinery approach using mainly NaDES to produce several high added-value ingredients from biomass is currently being developed.<\/p>\n

__________<\/strong><\/p>\n

<\/strong>
SIMBA 31, avenue Monge
37200 Tours France
https:\/\/simba.univ-tours.fr\/<\/em><\/a><\/p>\n

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Experimental facilities<\/h3>\n

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  • Centrifugal Partition Chromatography (CPC)<\/li>\n
  • High Performance Liquid Chromatography (HPLC)<\/li>\n
  • HPTLC automated chain <\/li>\n
  • Reveleris X2 Flash Chromatography purifier with UV + universal detectors<\/li>\n
  • Gas chromatography<\/li>\n
  • Microwave synthesis<\/li>\n
  • Microplate reader<\/li>\n
  • IR-ATR spectrometer<\/li>\n
  • X-Ray diffractometer<\/li>\n
  • LC-ESI-MS chain<\/li>\n
  • X-ray fluorescence spectrometer<\/li>\n<\/ul>\n

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