{"id":1910,"date":"2022-09-21T11:29:14","date_gmt":"2022-09-21T09:29:14","guid":{"rendered":"https:\/\/cosmetosciences.fr\/project\/molecular-biophysics-centre-upr-4301\/"},"modified":"2022-12-05T15:19:34","modified_gmt":"2022-12-05T14:19:34","slug":"molecular-biophysics-centre-upr-4301","status":"publish","type":"project","link":"https:\/\/cosmetosciences.fr\/en\/project\/molecular-biophysics-centre-upr-4301\/","title":{"rendered":"Molecular Biophysics Centre – UPR 4301"},"content":{"rendered":"

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CBM \u2022 UPR 4301
Molecular Biophysics Centre<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.18.0″ _module_preset=”default” text_font=”||on||||||” text_font_size=”18px” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]The Molecular Biophysics Centre, a unit specific to CNRS in Orl\u00e9ans (CNRS – UPR4301), develops research at the interface between Chemistry, Biology and Physics into living molecular mechanisms and the dysfunctions that lead to the development of certain diseases.[\/et_pb_text][et_pb_text _builder_version=”4.18.0″ _module_preset=”default” text_font_size=”15px” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

The researchers at the CBM contribute to understanding of the structure, dynamics and interactions of biological macromolecules. In-vitro<\/em>, in-silico<\/em> in-cellulo<\/em> and in-vivo<\/em> approaches are combined to explore living mechanisms and the anomalies that lead to the development of certain diseases.
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The research carried out at the CBM is organised around 4 scientific topic-specific teams and a research support service.\n<\/p>\n

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Cosm\u00e9tosciences research topic:<\/h2>\n

Biological activity and safety<\/h2>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/cosmetosciences.fr\/wp-content\/uploads\/2022\/09\/centre-biophysique-moleculaire-orleans.jpg” alt=”Molecular Biophysics Centre Building in Orl\u00e9ans” title_text=”centre-biophysique-moleculaire-orleans” _builder_version=”4.18.0″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” _builder_version=”4.17.4″ _module_preset=”default” custom_padding=”4px||18px|||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.18.0″ _module_preset=”default” header_2_font=”Comfortaa|700|||||||” header_2_line_height=”1.2em” header_3_line_height=”1.2em” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

CBM research is conducted in 16 topic-specific groups organised into 4 teams. Two teams are involved in Cosm\u00e9tosciences<\/h3>\n

[\/et_pb_text][et_pb_toggle title=”Fundamental and Translational Aspects in Health and Well-being team (AFTS)” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#C8B3A3″ closed_toggle_background_color=”#DD98A6″ icon_color=”#FFFFFF” use_icon_font_size=”on” icon_font_size=”30px” open_icon_color=”#7D5A40″ open_use_icon_font_size=”on” open_icon_font_size=”30px” _builder_version=”4.18.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|700|||||||” custom_margin=”||8px|||” hover_enabled=”0″ border_radii=”on|8px|8px|8px|8px” border_color_all=”#DD98A6″ global_colors_info=”{}” sticky_enabled=”0″]The Cellular micro-environment and pharmacology of receptors group studies the role of the micro-environment in the regulation of physiological processes (ageing) and pathological (tumour, inflammatory, oxidative stress micro-environments,\u2026). We develop various 2D and 3D cellular models (endothelial cells, nervous system cells, skin cells, tumour cells) respecting the rate of intratissular oxygenation, physioxia or hypoxia. Our goal is to identify the biomarkers involved in these processes, whether they are in the form of proteins, metabolites or microRNAs (new regulators of gene expression) and to study the dialogue between membrane receptors and the cellular micro-environment. We also develop new, powerful, selective pharmacological tools directed towards these receptors to improve our fundamental knowledge on the activation mechanisms of these receptors and for therapeutic applications.<\/p>\n

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Molecular Biophysics Centre<\/b>
\nRue Charles Sadron
\nCS 80054
\n45071 ORLEANS Cedex 2\u2028France
\nTel.: +33 (0)2 38 25 55 57<\/p>\n

http:\/\/cbm.cnrs-orleans.fr<\/em><\/a>[\/et_pb_toggle][et_pb_toggle title=”Cellular Signalling, Molecular Targets and Innovative Therapies team (SCT)” open_toggle_text_color=”#FFFFFF” open_toggle_background_color=”#C8B3A3″ closed_toggle_background_color=”#DD98A6″ icon_color=”#FFFFFF” use_icon_font_size=”on” icon_font_size=”30px” open_icon_color=”#7D5A40″ open_use_icon_font_size=”on” open_icon_font_size=”30px” _builder_version=”4.18.0″ _module_preset=”default” title_text_color=”#FFFFFF” title_font=”|700|||||||” custom_margin=”||8px|||” hover_enabled=”0″ border_radii=”on|8px|8px|8px|8px” border_color_all=”#DD98A6″ global_colors_info=”{}” sticky_enabled=”0″]The team\u2019s principal centres of interest are: cancer, neurodegenerative disorders and skin biology. The team brings together specialist researchers in cellular and molecular biology, biochemistry, physicochemistry and pharmacology. The projects developed combine fundamental research and translational research in biochemistry and molecular and cellular biology and are carried out in conjunction with the use of cellular and animal models in order to decode on a molecular scale, the biological processes brought into play under different physiological or pathological conditions.\u2028A significant part of the projects consists in the development of new therapeutic strategies to identify new biomarkers and new targets for specific disorders thanks to fine knowledge of the cellular processes including gene expression (RNA biology) and signalling cascades. The data obtained from the fundamental studies will be used to perfect innovative therapies including the design and vectorisation of therapeutic agents.<\/p>\n

__________<\/b><\/p>\n

Molecular Biophysics Centre<\/b>
\nRue Charles Sadron
\nCS 80054
\n45071 ORLEANS Cedex 2\u2028France
\nTel.: +33 (0)2 38 25 55 57<\/p>\n

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Experimental facilities<\/h3>\n

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  • Cellular biology<\/b>
    \u2022 Culture rooms, one of which is P2 level
    \u2022 Hypoxia chambers with oxygen rate control
    \u2022 Hypoxia workstation
    \u2022 Blood flow reconstitution equipment
    \u2022 Flow cytometers
    \u2022 Cell sorters
    \u2022 Video microscopes
    \u2022 Confocal microscope
    \u2022 Microscope\/micromanipulator workstation for the dissection of yeast tetrads (Singer MSM 300)<\/li>\n
  • Molecular biology
    <\/b>\u2022 Quantitative PCR
    \u2022 Droplet digitalTM<\/li>\n
  • Biochemistry<\/b>\n

    \u2022 MSM System yeast dissector
    \u2022 Cell fractionation and tissue grinding machines
    \u2022 FPLC system for the purification of proteins
    \u2022 Biacore 3000
    \u2022 UV-Visible microspectrophotometer
    \u2022 Absorbance, fluorescence, luminescence, polarised fluorescence, delayed fluorescence microplate reader
    \u2022 Imaging device for chemiluminescense
    \u2022 UV irradiator
    \u2022 ZetaSizer 3000<\/p>\n<\/li>\n<\/ul>\n

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    Are you looking for a specific laboratory or contact?
    Select one of the 2 criteria, or both at the same time<\/strong><\/h3>\n

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    • contacts<\/span>