ICOA • UMR 7311
Institute of Organic and Analytical Chemistry

The Institute of Organic and Analytical Chemistry – ICOA is a research laboratory under the supervision of the University of Orléans and the CNRS (UMR 7311), located on the campus of the university. The mission of the laboratory is the identification of new bioactive molecules that could have therapeutic and cosmetic applications.

ICOA laboratory building at the University of Orléans

Cosmétosciences research topics:

Naturalness and eco-friendly processes and Biological activity and safety

The scientific approach extends from the design of new structures by molecular modelling, to the synthesis of new organic molecules (heterocyclic compounds, sugar derivatives and nucleoside analogues), to the extraction and characterisation of natural molecules by the most effective separation and extraction techniques and by mass spectrometry, and to enzymology, to learn about the receptors of certain bioactive molecules .

The ICOA’s research is conducted by 5 teams. 4 of them are involved with Cosmétosciences

The Structural Bioinformatics and Cheminformatics team

The ICOA’s Structural Bioinformatics and Cheminformatics team of the University of Orléans is developing and using new in silico methods applied to the understanding of molecular systems and to biomolecular interactions in the field of therapeutic innovation, cosmetics and analytical chemistry.

The methods used are molecular modelling, approaches based on the structure of proteins or ligands, cheminformatics, structural bioinformatics, the development of relational databases and data viewing methods.

GlycoBio&Chemistry research team
The GlycoBio&Chemistry research team is interested in the development of new methodologies for the synthesis of glycosylated molecules such as glycosaminoglycans, glycomimetics (iminosugars, thiosugars) as well as the monomers, oligomers and polymers of biosourced surfactants. And also in chemo-enzymatic synthesis and the study of the structure and action mechanisms of glycosyltransferase and glycosidases to perform molecular engineering.
The Heterocycles, Nucleosides and Imaging Agents team (HNAI)
The Heterocycles, Nucleosides and Imaging Agents team is developing methodologies for the synthesis and functionalisation of heterocycles and rare heteroaromatics, as well as nucleoside and nucleotide analogues.
It is synthesising new chemical tools with a view to their use in medicinal biology and chemistry ‘Chemical Biology’: probes and sensitisers for in vitro and in vivo imaging for the pharmaceutical and cosmetics field and is developing innovative methods for detecting and evaluating the toxicity/safety of bioactive molecules.
The Analytical Strategies, Affinities and Bioactive ingredients team (SAAB)
The ICOA’s Extraction & Analysis of Bioactive Molecules team is developing methods for analysing molecules of interest that are present in trace amounts in complex environments. And also new eco-friendly methodologies for the extraction, separation, isolation, characterisation,’identification, and dosage of the primary and secondary metabolites present in plants. The biological activities of extracts that are of cosmetic or therapeutic interest are evaluated by chemical and biochemical in vitro reactions. Chemometric and and bioinformatic tools are also developed to optimise analysis conditions, to perform mapping and for complex sample comparisons.

Experimental facilities

  • The research teams are supported by 4 platforms (organic synthesis, biochemistry, analysis techniques and a chemical library), which are autonomous, functioning for both internal and external projects.
  • Triple quadrupole mass spectrometers, Maldi Tof, Q-Tof
  • HPLC, nano-LC, UPLC, SFC, GC, CE, HPTLC, CPC separation methods, light scattering detectors (DEDL)
  • Microwave, continuous flow, sonication and photochemistry devices

Contact details

Institute of Organic and Analytical Chemistry
University of Orléans – Chemistry cluster
rue de Chartres – BP 6759
45067 Orléans Cedex 2
France
Tel.: +33 (0)2 38 41 73 54
https://www.icoa.fr/

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  • contacts
    • contacts
    • Lavinia BALAN
    • Patrick BARIL
    • Hélène BENEDETTI
    • Pascal BONNET
    • Franck BONNIER
    • Stéphane BOSTYN
    • Ayache BOUAKAZ
    • Leslie BOUDESOCQUE-DELAYE
    • Frédéric BURON
    • Sabine CARPIN
    • Agnes CHARTIER
    • Igor CHOURPA
    • David DA SILVA
    • Emilie DESTANDAU
    • Catherine GRILLON
    • Samuel GUILLOT
    • Nathalie GIGLIOLI-GUIVARC'H
    • Christophe HANO
    • Pierre LAFITE
    • Frédéric LAMBLIN
    • Arnaud LANOUE
    • Eric LESELLIER
    • Emilie MUNNIER
    • Reine NEHMÉ
    • Chantal PICHON
    • Karen PLÉ
    • Eric ROBERT
    • Sylvain ROUTIER
    • Benoit SAINT PIERRE
    • Marie SCHULER
    • Christophe SINTUREL
    • Arnaud TATIBOUËT
    • Béatrice VALLÉE-MÉHEUST
  • Laboratories
    • Laboratories
    • CEMHTI (Conditions extrême et Matériaux : Haute Température et Irradiation)
    • BBV (Biomolécules et Biotechnologies Végétales)
    • CBM (Centre de Biophysique Moléculaire)
    • GREMI (Groupe de Recherches sur l'Energétique des Milieux Ionisés)
    • IBRAIN (Imagerie & Cerveau)
    • ICMN (Interfaces, Confinement, Matériaux et Nanostructures)
    • ICARE (Institut de Combustion, Aérothermique, Réactivité et Environnement)
    • ICOA (Institut de Chimie Organique)
    • LBLGC (Laboratoire de Biologie des Ligneux et des Grandes Cultures)
    • NMNS (Nanomédicaments et Nanosondes)
    • SIMBA (Synthèse et Isolement de Molécules Bioactives )