CBM • UPR 4301
Molecular Biophysics Centre

The Molecular Biophysics Centre, a unit specific to CNRS in Orléans (CNRS – UPR4301), develops research at the interface between Chemistry, Biology and Physics into living molecular mechanisms and the dysfunctions that lead to the development of certain diseases.

The researchers at the CBM contribute to understanding of the structure, dynamics and interactions of biological macromolecules. In-vitro, in-silico in-cellulo and in-vivo approaches are combined to explore living mechanisms and the anomalies that lead to the development of certain diseases.

The research carried out at the CBM is organised around 4 scientific topic-specific teams and a research support service.

Cosmétosciences research topic:

Biological activity and safety

Molecular Biophysics Centre Building in Orléans

CBM research is conducted in 16 topic-specific groups organised into 4 teams. Two teams are involved in Cosmétosciences

Fundamental and Translational Aspects in Health and Well-being team (AFTS)

The Cellular micro-environment and pharmacology of receptors group studies the role of the micro-environment in the regulation of physiological processes (ageing) and pathological (tumour, inflammatory, oxidative stress micro-environments,…). We develop various 2D and 3D cellular models (endothelial cells, nervous system cells, skin cells, tumour cells) respecting the rate of intratissular oxygenation, physioxia or hypoxia. Our goal is to identify the biomarkers involved in these processes, whether they are in the form of proteins, metabolites or microRNAs (new regulators of gene expression) and to study the dialogue between membrane receptors and the cellular micro-environment. We also develop new, powerful, selective pharmacological tools directed towards these receptors to improve our fundamental knowledge on the activation mechanisms of these receptors and for therapeutic applications.

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Molecular Biophysics Centre
Rue Charles Sadron
CS 80054
45071 ORLEANS Cedex 2 France
Tel.: +33 (0)2 38 25 55 57

http://cbm.cnrs-orleans.fr

Cellular Signalling, Molecular Targets and Innovative Therapies team (SCT)

The team’s principal centres of interest are: cancer, neurodegenerative disorders and skin biology. The team brings together specialist researchers in cellular and molecular biology, biochemistry, physicochemistry and pharmacology. The projects developed combine fundamental research and translational research in biochemistry and molecular and cellular biology and are carried out in conjunction with the use of cellular and animal models in order to decode on a molecular scale, the biological processes brought into play under different physiological or pathological conditions. A significant part of the projects consists in the development of new therapeutic strategies to identify new biomarkers and new targets for specific disorders thanks to fine knowledge of the cellular processes including gene expression (RNA biology) and signalling cascades. The data obtained from the fundamental studies will be used to perfect innovative therapies including the design and vectorisation of therapeutic agents.