NMNS • EA 6295
Nanomedicines and Nanoprobes laboratory

The Nanomedicines and Nanoprobes laboratory (NMNS) is a team whose collective complementary skills are used for the development and study of biocompatible nanoparticles, vectors of anticancer agents (nanomedicines – NM) and/or imaging agents (nanoprobes – NS).

The Nanomedicines and Nanoprobes research laboratory

Cosmétosciences research topic:

Formulation and sensoriality

Theranostic (therapeutic and diagnostic) treatment of cancers and dermatology/cosmetology are the two main areas of application of the research activities.
The multidisciplinary nature of the team allows a complete study of these new nanoforms, including their design, physico-chemical characterisation and biological evaluation in vitro and in vivo.
New bio-analysis and diagnosis approaches, based on methodologies such as Raman spectroscopy, capillary electrophoresis and spectral and optical imaging, are developed to elucidate the relationship between the physico-chemical properties of nanoparticles and their biological activities.

The NMNS’s research is conducted by 2 teams. One team is involved in Cosmétosciences

Nanomedicine, nanoformulation team

  • Synthesis of molecular conjugates (polymer-peptide, polymer-antibody fragment) (KHA)
  • Synthesis of metallic and bi-metallic nanoparticles (iron oxides, silver, gold) (KHA, IC)
  • Surface functionalisation of nanosystems (organosilane chemistry, thiol chemistry.) (KHA)


  • Assembly of nanosystems by electrostatic interactions (SD, HM)
  • Nanoencapsulation of hydrophilic/hydrophobic active compounds (biocompatible polymers, lipids, cosmetological active agents) (EM, HM)

Analysis of molecules and nanosystems:

  • HPLC, capillary electrophoresis (MS, LDE)
  • FT-IR, Raman, UV-visible (FB, CI)
  • Multimodal imaging:

In vitro: IR/Raman/Fluorescence Spectral Microscopy (IC, FB)
in vivo: MRI-Fluorescence-Surface Enhanced Raman (SERS) coupling (IC)


31, avenue Monge
37200 Tours

Experimental facilities

  • Raman confocal microspectrometer/laser scan fluorescence
  • Eppendorf InjectMan Micromanipulator/Eppendorf FemtoJet injector
  • Capillary electrophoresis fitted with a diode array detector strip and a laser-induced fluorescence detector
  • UHPLC chromatography
  • Gas chromatography
  • Granulometer and zeta meters
  • FT-IR spectrophotometers
  • Spectrofluorimeters
  • Atomic absorption spectrophotometer
  • Imager of electrophoresis gels and WB membranes
  • Thermostatically controlled reactor with IKA foaming agent to perfect paste products
  • Rheometer
  • Laminar flow hood for cell culture

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  • contacts
    • contacts
    • Lavinia BALAN
    • Patrick BARIL
    • Hélène BENEDETTI
    • Pascal BONNET
    • Franck BONNIER
    • Stéphane BOSTYN
    • Ayache BOUAKAZ
    • Frédéric BURON
    • Sabine CARPIN
    • Agnes CHARTIER
    • Igor CHOURPA
    • David DA SILVA
    • Emilie DESTANDAU
    • Catherine GRILLON
    • Samuel GUILLOT
    • Christophe HANO
    • Pierre LAFITE
    • Frédéric LAMBLIN
    • Arnaud LANOUE
    • Eric LESELLIER
    • Emilie MUNNIER
    • Reine NEHMÉ
    • Chantal PICHON
    • Karen PLÉ
    • Eric ROBERT
    • Sylvain ROUTIER
    • Benoit SAINT PIERRE
    • Marie SCHULER
    • Christophe SINTUREL
    • Arnaud TATIBOUËT
    • Béatrice VALLÉE-MÉHEUST
  • Laboratories
    • Laboratories
    • CEMHTI (Conditions extrême et Matériaux : Haute Température et Irradiation)
    • BBV (Biomolécules et Biotechnologies Végétales)
    • CBM (Centre de Biophysique Moléculaire)
    • GREMI (Groupe de Recherches sur l'Energétique des Milieux Ionisés)
    • IBRAIN (Imagerie & Cerveau)
    • ICMN (Interfaces, Confinement, Matériaux et Nanostructures)
    • ICARE (Institut de Combustion, Aérothermique, Réactivité et Environnement)
    • ICOA (Institut de Chimie Organique)
    • LBLGC (Laboratoire de Biologie des Ligneux et des Grandes Cultures)
    • NMNS (Nanomédicaments et Nanosondes)
    • SIMBA (Synthèse et Isolement de Molécules Bioactives )