SIMBA • EA 7502
Synthesis and Isolation of Bioactive Molecules laboratory

The Synthesis and Isolation of Bioactive Molecules laboratory (SIMBA) is an EA7502 host team from the University of Tours created in January 2018, which works on small molecules with the aim of therapeutic application. These are obtained by synthetic chemistry or isolated from plants or algae.

The entire SIMBA laboratory team

Cosmétosciences research topic:

Naturalness and eco-friendly processes

The SIMBA team is therefore developing new methodologies for the synthesis of heterocyclic and/or fluorinated compounds, based on organometallic chemistry, extraction and analysis by various chromatographic methods (HPTLC, CPC) of natural substances, and the use of deep eutectic solvents.
The molecular diversity obtained can be applied to infectious diseases, oncology and cosmetology.

The SIMBA’s research is conducted by 2 teams.
One team is involved in Cosmétosciences

Eco-friendly biomass extraction team

The component of the laboratory working on eco-friendly biomass extraction is studying the use of Natural Deep Eutectic Solvent (NaDES) as an advantageous alternative for biomass extraction. NaDES are considered to be a new generation of ionic liquids, consisting of a hydrogen bond acceptor (HBA) and a hydrogen bond donor (HBD), the combination of which forms a hydrogen bond network resulting in the lowering of the melting point of the solids mixture.

The team is currently working on the development of an innovative library of new NaDES, apolar ones in particular, from their design to their characterisation, and including the development of new processes for obtaining them.
These NaDES are used for the extraction of microalgae and plants in partnership with manufacturers, with the aim of enhancing their metabolites. A multi-step biorefinery approach using mainly NaDES to produce several high added-value ingredients from biomass is currently being developed.


SIMBA 31, avenue Monge
37200 Tours France

Experimental facilities

  • Centrifugal Partition Chromatography (CPC)
  • High Performance Liquid Chromatography (HPLC)
  • HPTLC automated chain
  • Reveleris X2 Flash Chromatography purifier with UV + universal detectors
  • Gas chromatography
  • Microwave synthesis
  • Microplate reader
  • IR-ATR spectrometer
  • X-Ray diffractometer
  • LC-ESI-MS chain
  • X-ray fluorescence spectrometer

Are you looking for a specific laboratory or contact?
Select one of the 2 criteria, or both at the same time

  • contacts
    • contacts
    • Lavinia BALAN
    • Patrick BARIL
    • Hélène BENEDETTI
    • Pascal BONNET
    • Franck BONNIER
    • Stéphane BOSTYN
    • Ayache BOUAKAZ
    • Frédéric BURON
    • Sabine CARPIN
    • Agnes CHARTIER
    • Igor CHOURPA
    • David DA SILVA
    • Emilie DESTANDAU
    • Catherine GRILLON
    • Samuel GUILLOT
    • Christophe HANO
    • Pierre LAFITE
    • Frédéric LAMBLIN
    • Arnaud LANOUE
    • Eric LESELLIER
    • Emilie MUNNIER
    • Reine NEHMÉ
    • Chantal PICHON
    • Karen PLÉ
    • Eric ROBERT
    • Sylvain ROUTIER
    • Benoit SAINT PIERRE
    • Marie SCHULER
    • Christophe SINTUREL
    • Arnaud TATIBOUËT
    • Béatrice VALLÉE-MÉHEUST
  • Laboratories
    • Laboratories
    • CEMHTI (Conditions extrême et Matériaux : Haute Température et Irradiation)
    • BBV (Biomolécules et Biotechnologies Végétales)
    • CBM (Centre de Biophysique Moléculaire)
    • GREMI (Groupe de Recherches sur l'Energétique des Milieux Ionisés)
    • IBRAIN (Imagerie & Cerveau)
    • ICMN (Interfaces, Confinement, Matériaux et Nanostructures)
    • ICARE (Institut de Combustion, Aérothermique, Réactivité et Environnement)
    • ICOA (Institut de Chimie Organique)
    • LBLGC (Laboratoire de Biologie des Ligneux et des Grandes Cultures)
    • NMNS (Nanomédicaments et Nanosondes)
    • SIMBA (Synthèse et Isolement de Molécules Bioactives )